Research Topic DNA helicases: expression, functions and clinical implications. Overview Articles Authors Impact. Topic Editors. Views Demographics No records found total views article views article downloads topic views. Top countries. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. DSB repair and homologous recombination HR. RecQ helicases. The role of DNA helicases and their interaction partners in genome stability and meiotic recombination in plants.
Alexander Knoll , Alexander Knoll. Oxford Academic. E-mail: Holger. Puchta kit. Revision received:. Select Format Select format. Permissions Icon Permissions. Chromatin remodelling , DNA repair , double strand break , genome stability , helicase , homologous recombination , meiosis , translocase. Open in new tab Download slide. Table 1. Fungal and human homologues of plant helicases. Open in new tab. Table 2. Phenotypes of plant DNA helicases. Differential timing and control of noncrossover and crossover recombination during meiosis.
Google Scholar Crossref. Search ADS. Arabidopsis RecQsim, a plant-specific member of the RecQ helicase family, can suppress the MMS hypersensitivity of the yeast sgs1 mutant. RTEL1 maintains genomic stability by suppressing homologous recombination. Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes.
Recombinational repair in yeast: functional interactions between Rad51 and Rad54 proteins. Google Scholar PubMed. The Srs2 helicase activity is stimulated by Rad51 filaments on dsDNA: implications for crossover incidence during mitotic recombination. Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process.
The INO80 protein controls homologous recombination in Arabidopsis thaliana. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Molecular characterisation of RecQ homologues in Arabidopsis thaliana. Topoisomerase 3alpha and RMI1 suppress somatic crossovers and are essential for resolution of meiotic recombination intermediates in Arabidopsis thaliana.
Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana. Mechanisms of nucleic acid translocases: lessons from structural biology and single-molecule biophysics.
The single-end invasion: an asymmetric intermediate at the double-strand break to double-Holliday junction transition of meiotic recombination. Species-specific double-strand break repair and genome evolution in plants.
Cooperative roles of vertebrate Fbh1 and Blm DNA helicases in avoidance of crossovers during recombination initiated by replication fork collapse. A conserved and species-specific functional interaction between the Werner syndrome-like exonuclease atWEX and the Ku heterodimer in Arabidopsis.
Multifaceted role of the Saccharomyces cerevisiae Srs2 helicase in homologous recombination regulation. An expanded inventory of conserved meiotic genes provides evidence for sex in Trichomonas vaginalis. Two meiotic crossover classes cohabit in Arabidopsis: one is dependent on MER3, whereas the other one is not.
Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae. Isolation and genetic characterization of a thymineless death-resistant mutant of Escherichia coli K identification of a new mutation recQ1 that blocks the RecF recombination pathway.
Efficient copying of nonhomologous sequences from ectopic sites via P-element-induced gap repair. Different pathways of homologous recombination are used for the repair of double-strand breaks within tandemly arranged sequences in the plant genome. Isolation and characterization of the RAD54 gene from Arabidopsis thaliana. Homologous recombination and maintenance of genome integrity: cancer and aging through the prism of human RecQ helicases.
Genetic evidence for a role of Saccharomyces cerevisiae Mph1 in recombinational DNA repair under replicative stress. Biochemical characterization of an exonuclease from Arabidopsis thaliana reveals similarities to the DNA exonuclease of the human Werner syndrome protein. Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase.
Yeast Mph1 helicase dissociates Radmade D-loops: implications for crossover control in mitotic recombination. The repair of double-strand breaks in plants: mechanisms and consequences for genome evolution. The yeast Pif1 helicase prevents genomic instability caused by G-quadruplex-forming CEB1 sequences in vivo. Capture of genomic and T-DNA sequences during double-strand break repair in somatic plant cells.
Characterization of four RecQ homologues from rice Oryza sativa L. MPH1, a yeast gene encoding a DEAH protein, plays a role in protection of the genome from spontaneous and chemically induced damage. Yeast MPH1 gene functions in an error-free DNA damage bypass pathway that requires genes from homologous recombination, but not from postreplicative repair. High-frequency gene targeting in Arabidopsis plants expressing the yeast RAD54 gene.
Genome-wide association study identifies five susceptibility loci for glioma. Efficient repair of genomic double-strand breaks by homologous recombination between directly repeated sequences in the plant genome. Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S.
Van Maldergem. SGS1, a homologue of the Bloom's and Werner's syndrome genes, is required for maintenance of genome stability in Saccharomyces cerevisiae. Sgs1: a eukaryotic homolog of E. The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha.
Evolution of F-box genes in plants: different modes of sequence divergence and their relationships with functional diversification. BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity. All rights reserved. For Permissions, please e-mail: journals. Issue Section:. Download all slides. Comments 0. Add comment Close comment form modal.
I agree to the terms and conditions. You must accept the terms and conditions. Add comment Cancel. Submit a comment. Comment title. You have entered an invalid code. Submit Cancel. Thank you for submitting a comment on this article. Your comment will be reviewed and published at the journal's discretion. Please check for further notifications by email. View Metrics. Email alerts Article activity alert. Advance article alerts. New issue alert.
Receive exclusive offers and updates from Oxford Academic. Related articles in Web of Science Google Scholar. Citing articles via Web of Science Did breeding alter the light environment, photosynthetic apparatus and photosynthetic capacity of wheat leaves? The proteome of developing barley anthers during meiotic prophase I.
The epigenetic mechanisms regulating floral hub genes and their potential for manipulation. A novel chicory fructanase can degrade common microbial fructan product profiles and displays positive cooperativity. Hartung et al. Unwinds partial duplex structures in vitro ; branch migrates a partially mobile HJ structure in vitro ; promotes fork regression of a model replication fork in vitro.
Bagherieh-Najjar et al. Hartung and Puchta Expressed in meristematic tissues; induction of expression by genotoxic agents; GFP fusion protein detected in plastids; involved in gene silencing. Saotome et al. Expressed in meristematic tissues; induction of expression by genotoxic agents; GFP fusion protein detected in plastids. Expressed in meristematic tissues; induction of expression by genotoxic agents; GFP fusion protein detected in nucleus.
Blanck et al. Fritsch et al. March-Diaz and Reyes Klutstein et al. This is carried out by an enzyme called helicase which breaks the hydrogen bonds holding the complementary bases of DNA together A with T, C with G. The two separated strands will act as templates for making the new strands of DNA.
As a result of their different orientations, the two strands are replicated differently: An illustration to show replication of the leading and lagging strands of DNA. Related Content:. What is a genome?
What is DNA? What is a cell? How helpful was this page?
0コメント